Set one month after the events in the movie, the series focuses on Sara Maguire, a nurse who is attacked by a vampire and slowly transforms into one. She is tracked down by Nick Maguire, her brother, Gina, an FBI agent, and George Fowler, the vampire hunter from "30 Days of Night Blood Trails."
President Grant orders Indian fighter MacKay to negotiate with the Modocs of northern California and southern Oregon. On the way he must escort Nancy Meek to the home of her aunt and uncle. After Modoc renegade Captain Jack engages in ambush and other atrocities, MacKay must fight him one-on-one with guns, knives and fists.